72. Cerebral Metabolism Following Severe Head Injury

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Cerebral endothelial damage after severe head injury.

We demonstrate that in head injuries the degree of cerebral endothelial activation or injury depends on the type of brain injury and the patients age, and that in severe head injuries measuring the serum levels of thrombomodulin (TM) and von Willebrand factor (vWF) is useful in evaluating cerebral endothelial injury and activation. The values of vWF in the cases of focal brain injury were signi...

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Diffuse degeneration of the cerebral white matter in severe dementia following head injury.

This paper reports the findings in the brains of five patients who' survived a closed head injury in a more or less decerebrate and extremely demented state, for five to 15 months. These cases were selected from a series of patients who died after prolonged coma or other severe disturbances of consciousness following head injury. Both clinically and pathologically they form a distinct group. Th...

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Hyperventilation following head injury: effect on ischemic burden and cerebral oxidative metabolism.

OBJECTIVE To determine whether hyperventilation exacerbates cerebral ischemia and compromises oxygen metabolism (CMRO2) following closed head injury. DESIGN A prospective interventional study. SETTING A specialist neurocritical care unit. PATIENTS Ten healthy volunteers and 30 patients within 10 days of closed head injury. INTERVENTIONS Subjects underwent oxygen-15 positron emission tom...

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Differential influence of arterial blood glucose on cerebral metabolism following severe traumatic brain injury

INTRODUCTION Maintaining arterial blood glucose within tight limits is beneficial in critically ill patients. Upper and lower limits of detrimental blood glucose levels must be determined. METHODS In 69 patients with severe traumatic brain injury (TBI), cerebral metabolism was monitored by assessing changes in arterial and jugular venous blood at normocarbia (partial arterial pressure of carb...

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Head injury (moderate to severe): reducing cerebral oedema

INTRODUCTION: Head injury in young adults is often associated with motor vehicle accidents, violence, and sports injuries. In older adults, it is often associated with falls. Severe head injury can lead to secondary brain damage from cerebral ischaemia resulting from hypotension, hypercapnia, and raised intracranial pressure. Severity of brain injury is assessed using the Glasgow Coma Scale (GC...

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ژورنال

عنوان ژورنال: Neurologia medico-chirurgica

سال: 1971

ISSN: 0470-8105,1349-8029

DOI: 10.2176/nmc.11.172